Study of oxidative stress in pre- and post-hemodialysis in chronic renal failure patients

Chronic renal failure is a progressive loss of renal function over a period of months or year and Hemodialysis is a suitable treatment which is preferably given to the chronic renal failure ernment RF) . Who are not to undergo renal transplantation therapy. This study was carried out to observe the immediate effect of oxidative stress and inflammation during hemodialysis . In the present study 30 CRF patients undergoing hemodialysis and 50 healthy controls matching in age and sex were included. In the present study prehemodialytic samples showed significant rise (P<0.001) in serum lipid peroxidation (LPO), serum homocysteine and high sensitivity C-reactive Protein (hs-CRP) as compared to controls. Mean values of serum superoxide dismutase (SOD) and serum nitric oxide (NO● )were found to be significantly reduced (P<0.001)in prehemodialytic samples as compared to controls. In post hemodialytic samples mean values of serum superoxide dismutase, serum nitric oxide and serum homocysteine were significantly reduced (P<0.001)when compared to prehemodialytic samples while mean values of serum lipid peroxidation and hs-CRP were significantly increased (P<0.001)in post hemodialytic samples as compared to prehemodialytic samples. The result of our study have been shown there is extensive oxidative stress and inflammation in patients with CRF, which is further augmented by hemodialysis, as supported by altered levels of LPO, SOD, NO●, homocysteine and hs-CRP. It may cause increased risk of cardiovascular disorder (CVD) in patients on chronic hemodialysis.